[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
Identifieur interne : 002716 ( Main/Exploration ); précédent : 002715; suivant : 002717[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
Auteurs : C. Lacroix [France] ; P. Poncet ; G. Laine ; C. Guyonnaud ; M. Ray ; S. Menager ; O. LafontSource :
- Journal of chromatography ; 1987.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Pyrazinamide.
- chemical , analysis : Pyrazinamide.
- chemical , blood : Pyrazinamide.
- chemical , urine : Pyrazinamide.
- chemical : Indicators and Reagents.
- Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Humans, Spectrometry, Fluorescence, Spectrophotometry, Ultraviolet.
Abstract
The method reported here for determining pyrazinamide and its metabolites (2-pyrazinoic acid, 5-hydroxypyrazinamide, 5-hydroxypyrazinoic acid and pyrazinuric acid) consists of diluting urine or acid deproteinisation of serum followed by chromatography on a cation-exchange column. The column length and the detection system (ultraviolet or fluorimetry) allow for a very good separation of the different compounds; the sensitivity of the method makes it suitable for pharmacokinetic studies.
PubMed: 3437007
Affiliations:
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Le document en format XML
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<author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
<affiliation wicri:level="1"><nlm:affiliation>Unités de Pharmacocinétique, Centre Hospitalier Général, Le Havre, France.</nlm:affiliation>
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<placeName><settlement type="city">Le Havre</settlement>
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<author><name sortKey="Poncet, P" sort="Poncet, P" uniqKey="Poncet P" first="P" last="Poncet">P. Poncet</name>
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<author><name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G" last="Laine">G. Laine</name>
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<author><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C" last="Guyonnaud">C. Guyonnaud</name>
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<author><name sortKey="Ray, M" sort="Ray, M" uniqKey="Ray M" first="M" last="Ray">M. Ray</name>
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<author><name sortKey="Menager, S" sort="Menager, S" uniqKey="Menager S" first="S" last="Menager">S. Menager</name>
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<author><name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O" last="Lafont">O. Lafont</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].</title>
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<affiliation wicri:level="1"><nlm:affiliation>Unités de Pharmacocinétique, Centre Hospitalier Général, Le Havre, France.</nlm:affiliation>
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<placeName><settlement type="city">Le Havre</settlement>
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<author><name sortKey="Poncet, P" sort="Poncet, P" uniqKey="Poncet P" first="P" last="Poncet">P. Poncet</name>
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<author><name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G" last="Laine">G. Laine</name>
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<author><name sortKey="Menager, S" sort="Menager, S" uniqKey="Menager S" first="S" last="Menager">S. Menager</name>
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<author><name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O" last="Lafont">O. Lafont</name>
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<series><title level="j">Journal of chromatography</title>
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<term>Indicators and Reagents</term>
<term>Pyrazinamide (analogs & derivatives)</term>
<term>Pyrazinamide (analysis)</term>
<term>Pyrazinamide (blood)</term>
<term>Pyrazinamide (urine)</term>
<term>Spectrometry, Fluorescence</term>
<term>Spectrophotometry, Ultraviolet</term>
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<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Pyrazinamide</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Pyrazinamide</term>
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<front><div type="abstract" xml:lang="en">The method reported here for determining pyrazinamide and its metabolites (2-pyrazinoic acid, 5-hydroxypyrazinamide, 5-hydroxypyrazinoic acid and pyrazinuric acid) consists of diluting urine or acid deproteinisation of serum followed by chromatography on a cation-exchange column. The column length and the detection system (ultraviolet or fluorimetry) allow for a very good separation of the different compounds; the sensitivity of the method makes it suitable for pharmacokinetic studies.</div>
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<tree><noCountry><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C" last="Guyonnaud">C. Guyonnaud</name>
<name sortKey="Lafont, O" sort="Lafont, O" uniqKey="Lafont O" first="O" last="Lafont">O. Lafont</name>
<name sortKey="Laine, G" sort="Laine, G" uniqKey="Laine G" first="G" last="Laine">G. Laine</name>
<name sortKey="Menager, S" sort="Menager, S" uniqKey="Menager S" first="S" last="Menager">S. Menager</name>
<name sortKey="Poncet, P" sort="Poncet, P" uniqKey="Poncet P" first="P" last="Poncet">P. Poncet</name>
<name sortKey="Ray, M" sort="Ray, M" uniqKey="Ray M" first="M" last="Ray">M. Ray</name>
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<country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name>
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